Repeated IVF failure: What to do next? – Dr. Hrishikesh Pai

If you have tried everything to conceive, but nothing seems to be working, you might have chosen the option of IVF. But what to do if your IVF cycles also fail? It makes you think that there are no other options left for you. This situation can be very exhausting both physically and mentally. 

In this article, Dr. Hrishikesh Pai, from Bloom IVF center, one of the best IVF centers in Mumbai, sheds some light on what causes IVF failures repeatedly and what to do next.

What is repeated IVF failure?

If you have three or more unsuccessful consecutive IVF cycles it is called repeated IVF failure or RIF. In such cases, proper diagnosis and finding out the cause of these failures are necessary.

You need a good gynecologist to treat you with proper treatment and care. Dr. Hrishikesh Pai from Bloom IVF Centre, one of the best IVF centers in Mumbai, has 35+ years of experience and has successfully treated many people.

Causes of repeated IVF failures

According to Dr. Pai, the following are the reasons that you might be failing your IVF cycles:

Poor Quality of Oocyte:

As a woman starts aging, the oocyte quality might reduce. During embryo formation, an oocyte is very important for dividing cells and chromosomal duplication.

If the quality of the oocyte is poor, it might result in the DNA being damaged and a chromosomal embryo.

Poor Quality of Sperm:

If the sperm quality is poor, the sperm sometimes might be unable to break the egg’s outer layer, which sometimes results in poor fertilization in the IVF failures.

Issues with Embryo transfer:

Embryo transfer is a sensitive and non-surgical procedure but needs to be done at the right time and carefully. Not doing it correctly can increase the risk of failed IVF cycles.

Issues of the uterus:

There might be some issues in your uterus that can lead to IVF failure. That is why it is essential to perform a thorough search of your uterus for conditions like hormones, fibroids, difficult cervix, a uterus shaped abnormally, chronic infections, swelling of the fallopian tubes, etc. can affect the failure of IVF.

Selection of the wrong embryo:

If your IVF specialist selects an abnormal embryo, the uterus might reject this embryo. So it is essential to choose the right embryo.


The critical point in the treatment of failed IVF is its diagnosis. If a doctor can detect the exact cause of the issue, your treatment can become more accessible.

The IVF specialist needs to check all the critical points while doing the IVF procedure, like selecting the correct embryo, healthy sperm and oocyte, checking the uterus environment, etc.

They need to avoid the mistakes that have been made in the past IVF cycles to succeed in the present one.

At Bloom IVF Centre, one of the best IVF centers in Mumbai, really good treatment is available.


According to Dr. Pai, following are the ways to diagnose RIF: 

Evaluation of the Uterus

In this test, the doctors look at your uterus and fallopian tube to make sure that there are no issues with them. A blocked fallopian tube filled with fluid can reduce the implantation by fifty percent. 

Sperm DNA Fragmentation Test

The test takes a look at the DNA quality of the sperm. If the sperm DNA fragmentation is very high, it could fail IVF. 

Immunologic Tests

These tests are use to determine immunologic abnormalities. It can help determine the cause of the previous failed IVF cycle before proceeding with the next one. 

Other tests are also performed like Endometrial Receptivity Assay and Preimplantation Genetic Testing that help determine the receptivity of the uterus regarding the implantation and checking chromosomes in the embryo, respectively.


Failing at your IVF cycle repeatedly can take a toll on your mental, physical and emotional state. It can make you feel like your dream of becoming a parent may never get fulfill. But the next step you need to take after repeated IVF failures is to visit a good gynecologist and determine what steps you will take next.

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